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Clomid, Medicated IUI, or Straight to IVF?


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Highlights from this Creating a Family radio show

It is so hard to know how long to stay at each level of infertility treatment. How many months on Clomid, how many IUIs (artificial inseminations) and how many cycles of IVF is reasonable before moving to donor egg? What is the best way to manage your fertility dollars and still get pregnant? Our guests were Dr. Alison Zimon, a reproductive endocrinologist at Boston IVF, and Dr. Samantha Pfeifer, Associate Professor of Obstetrics and Gynecology at University of Pennsylvania Medical School.

  • What has been the standard fertility treatment protocol in the past for the average infertility patient-assuming her infertility is female factor or unexplained?
  • How many months is the usual suggested time to try Clomid (clomiphene citrate)?
  • How effective is Clomid?
  • What are other drugs are similar to Clomid which are the first line of attack against infertility?
  • What other options are available in the form of oral medication?
  • What are the differences between these medications?
  • If one is not effective, should you try a different medication?
  • there a cost difference?
  • What is the multiple birth rate with Clomiphene Citrate or Letrozole?
  • Does the effectiveness of Clomid or Letrozole decrease with age?
  • What can I do to increase the effectiveness of Clomid or Letrozole or other oral fertility medications?
  • Does the effectiveness of Clomid or Letrozole decrease with repeated cycles?
  • Does Robutussin increase your chances of getting pregnant?
  • What is a medicated IUI cycle?
  • What type of fertility medications are used with intrauterine insemination (IUI)/ artificial insemination?
  • What are the disadvantages of an injectable medicated IUI cycle?
  • Tell us about the FASTT (fast-track and standard treatment) Trial Study that was designed to determine if it was best to do a couple of cycles of injectable IUIs or go straight to in vitro fertilization?
  • How large was this study of artificial insemination with injectable gonadotropins vs. IVF?
  • Did it decrease multiples?
  • Is it more cost effective to do intrauterine insemination (IUI)/ artificial insemination with injectable gonadotropins or in vitro fertilization (IVF)?
  • Has there been other research along these lines?
  • How effective is intrauterine insemination (IUI)/ artificial insemination with injectable gonadotropins with women over 40?
  • How much does an average IUI with injectable gonadotropins cost vs. an IVF cycle?
  • What are the main disadvantages of IUI with injectable gonadotropins cycles?
  • Is there a way to avoid higher order multiple fetuses with medicated IUIs?
  • Is there a way to avoid twins and triplets with medicated IUIs?
  • How effective is an IUI/artificial insemination with Clomid? How much more effective than just Clomid with sex?

Date: January 25, 2012; Reaired November 13, 2013; June 25, 2014

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Are you primarily interested in?  Infertility     Adoption
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Creating a Family and in particular your radio show has been a lifeline to me over the past 2+ years. In the privacy of my home/car I have been connected with others whose family-building has been challenged and I have had access to invaluable information from experts that have helped us make better decisions. Thank you! ~ S. Potter

Creating a Family was such a great resource for me throughout the adoption, I remember even blogging about it the first time I discovered the radio show because I was so excited! I continue to benefit from your the shows even now, one year post adoption. Thank you for the good and important work you are doing. ~ A. Oliver

I just wanted to say thank you so much for this resource, I just recently found it and I just happened to stumble upon it doing a google search.  It has been hugely helpful!!!! We've been looking into foster care and adoption and listening to the various radio shows relating to those topics have really helped us know what to do and what to expect..more  ~J. Joy

I just wanted to stop in and say a quick thank you for all the support and information you provide the adoption/infertility community... I also am a "research junkie", and your blogs & podcasts have been an invaluable source for us on our journey to grow our family. more ~ E. Meyer

I wanted to thank you for all of the wonderful things you do. We brought our beautiful baby boy home from the hospital on April 2nd. While we waited for an adoption match and then waited for his birth, your podcast and website were a continuous reminder that we were part of an amazing adoption community. It really helped us not feel alone.  ~Sarah S.

I listen to your radio shows daily on my iPod while cleaning, exercising, driving etc. I've learned so much from it, that today in the foster- adopt support group I felt like an all knowing expert, despite the fact, that I have zero experience in the field. Thank you for a wonderful resource! I am spreading the word. ~G. Longley

Thank you so much for your radio show! I was just listening to it, and it's very informative. My husband and I are in the process of adoption, so we read a lot to be able to make informed decisions. Your website is a great resource for us! ~N.M.W.

“I learned more from this show than from two Reproductive Endocrinologist and all my own research. I appreciate the professionals you have on your show.” ~ L. Upton

I LOVE your show, it's the most helpful, unbiased information I’ve found about infertility and adoption and I'm so thankful for you and your organization. Keep up the fantastic work, you are changing lives. ~ Amanda

So I would like to introduce to you....Z. V.. She is now 11 weeks old. She came from a lovely perfect little frozen embryo, from our 4th round of IVF (2 fresh cycles and 2 FET)...more  ~A. Houston

I'm just writing to say that I've downloaded another bunch of your podcasts onto my iPhone and while I listen to them on my daily commute I silently
thank you for doing such a good job and conducting such brilliant interviews!!!...
more   ~G. Marino

Although you don't know us from Adam, I wanted to drop a line and thank you for the amazing info, sound advice, and encouragement you offer to adoptive and prospective adoptive parents.  We just received our pre-approval for our daughter, W, from China!  You (in book, website, blog, and podcast form) have been there every step of the way in this journey.  ~ J. & C. Morningstar

I just wanted to drop you a note and tell you how much I love your show. I recently got an iPhone and have been listening to them on iTunes. Your "What Adopted Teens Want Their Parents to Know" session was amazing!!!          ~A. Watson

My husband and I are parents through adoption to THE three most incredible children in the world. All via newborn domestic transracial.  I wanted to tell you how much I’ve enjoyed and benefitted from your web site.  I often refer potential adoptive parents who ask me for advice to your site. I especially enjoy your radio shows and today’s show on "Knowing When to Move from Infertility to Adoption" particularly resonated with me. ~N. Ferrari

I have loved, loved this radio show. It has been hands down the most helpful resource on this often painful and confusing journey. ~ R. Butler

I have been listening to lots of your radio shows of late. Great guests and very enlightening always. Thanks so much for keeping us up with the latest.  ~ W. & M. Welch

I just wanted you to know what a tremendous resource and blessing your podcasts have been to my wife and I as we prepare to travel early next month to pick up our new 17 month old son from Colombia...more
~ M. & L. Oakes

I just wanted to share my story since Creating a Family pod casts were so helpful to me when I was infertile. It really helped knowing I wasn't alone and could get the most updated information on my condition. I am almost 32 years old and I have been trying to get pregnant for 6 long years...more ~ J. Mendenhall


You are the REAL DEAL—Thank you for your guidance, radio show, information, knowledge, resources, care & wisdom to know what is needed when.     ~ S. Miller 

We are awaiting the arrival of our child from Ethiopia. I recently took a road trip and downloaded 9 hours of the Creating a Family podcasts and listened to them all. I learned so much. Thanks.        ~J. Madine 

Just home from adopting our son in Colombia. He and we are doing great. Your site and especially podcasts were a tremendous resource to us personally, as well as for a reason we didn't ever expect...more  

~ M. and L. Oakes




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